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I presume the Nutra-Vet would be safe for puppies, but I'm not sure why you'd want to be giving them that sort of supplement at that age. You really want to focus on making sure you're giving them a excellent-quality, no grain food with ample protein and sources of calcium then. The Wellness 5 foods are good; and if you want to add a bit of extra calcium to their food easily; microwave eggshells for a minute; then grind in coffee grinder until very fine and sprinkle 1/4 tsp over food. I generally don't start giving Glucosamine until after age 2.